TEMPO and HPAO1 may indeed function as antioxidants reducing free radical damage to the polymer and increasing wear resistance of the polymer, 5 , 10 however, their biological effects may be significant in terms of their cytotoxicity.
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In vitro analysis of the cytotoxic and anti-inflammatory effects of antioxidant compounds used as additives in ultra high-molecular weight polyethylene in total joint replacement components.
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