Earlier studies have already shown that transfection per se causes disruption of the ERGIC and Golgi [ 37 , 38 ], but the breakdown observed with the frameshift mutant is highly significant compared to that observed with wild type or control transfections.
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A cataract-causing connexin 50 mutant is mislocalized to the ER due to loss of the fourth transmembrane domain and cytoplasmic domain.
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