Already after 4 weeks of diabetes, a time-point when no changes in aortic plaque size had yet occurred, expression of VCAM-1, MCP-1, IL-1β, Cox2, TF and maybe also IL-6 and ICAM-1 (borderline significance) were higher than in control non-diabetic mice.
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Inhibition of nuclear factor of activated T-cells (NFAT) suppresses accelerated atherosclerosis in diabetic mice.
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