Prolactin-induced protein (PIP) regulates proliferation of luminal A type breast cancer cells in an estrogen-independent manner.

A scatter plot of PIP expression versus that of the PIP-activated metagene across 557 BCa tumors revealed a highly significant positive correlation (r 2 = 0.4; p <0.0001), suggesting that in a clinical setting, PIP most likely regulates genes comprising the PIP-activated metagene as defined in the T47D/shPIP dox culture system ( Figure 2B ).

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