Neurological characterization of mice deficient in GSK3α highlight pleiotropic physiological functions in cognition and pathological activity as Tau kinase.

The cognitive performance, measured in the Y-maze task, revealed similar highly significant defects in GSK3α.KO and GSK3α.KOxTau.P301L mice in the number of entries and in alternations (p=0.0003 and p=0.0007 respectively; Table 2 ), although the index did not differ between either type of GSK3α-deficient mice and their respective controls.

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