Pharmacogenetics of chronic pain and its treatment.

Mediators Inflamm · 2013 · PMC3671679 · PMID 23766564

Europe PMC DOI

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borderline significantno p-value reported

The atypical opioid tramadol was proposed to be a subject of P-glycoprotein-dependent transport, as there were significant differences in its C max⁡ and borderline significant differences in AUC 0–24 amongst different genotypes for MDR1/ABCB1 in CYP2D6 poor metabolizers [ 85 ].

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