The schedule of administration of canakinumab in cryopyrin associated periodic syndrome is driven by the phenotype severity rather than the age.

Conversely, canakinumab treatment was associated with a significant amelioration of psychosocial concepts ( P = 0.03), especially for the parental emotional perception of the disease ( P = 0.045) with a trend towards significance for self-esteem ( P = 0.09) and parental time ( P = 0.1) (not shown).

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