Structural dynamics flexibility informs function and evolution at a proteome scale.

Interestingly, we found that the ASA difference between functionally critical and non-critical sites involved in catalytic or binding activity in our data set is not statistically significant ( P > 0.08), whereas the difference of dfi between these sites is highly significant with P < 0.00001 as also shown for residues located in loops ( Fig. 3 B).

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