This showed a highly significant upregulation in this gene set (Table 1 ) with Col1a1 (2.5-fold), bone sialoprotein ( Ibsp ) (2.6-fold), osteonectin ( Sparc ), (1.6-fold) and osteocalcin (BGlap1) (1.5-fold) all upregulated (all P < 0.03) (Table 2 ).
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Excessive bone formation in a mouse model of ankylosing spondylitis is associated with decreases in Wnt pathway inhibitors.
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