Models incorporating chromatin modification data identify functionally important p53 binding sites.

In contrast, there were highly significant and biologically relevant differences between the two models in the location of the predicted binding sites relative to genes, in the function of nearby genes and in the responsiveness of nearby genes to p53 activation.

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Interestingly, the improvement was barely significant in conventional ChIP assays of DNA binding, but stood out clearly in assays for functionally important differences.

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