Taken together, this analysis suggests that, despite no known role for LMO1 in normal haematopoietic cells, the gene is poised for expression in several haematopoietic lineages including T-lymphoid cells, which given its known function as a T-ALL oncogene is highly significant.
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Bivalent promoter marks and a latent enhancer may prime the leukaemia oncogene LMO1 for ectopic expression in T-cell leukaemia.
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