Empirical pathway analysis, without permutation.

Using safeExpress , we found several highly significant GO pathways for the various x vectors: (i) p53 mutation status in all patients; (ii) p53 mutation status for estrogen-receptor positive (ER+) tumors only ( n =213); (iii) p53 mutation status in all patients, with covariate adjustment for ER status; and (iv) the continuous martingale residuals for disease-free survival.

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