Vaccination with recombinant Mycobacterium tuberculosis PknD attenuates bacterial dissemination to the brain in guinea pigs.

While the modest decrease in pulmonary bacterial burden in the PknD vaccinated group at 6-weeks could have partially contributed to the decreased bacterial dissemination to the CNS, highly significant differences were noted in bacterial dissemination to the CNS even at 4-weeks, when the pulmonary bacterial burden in the PknD vaccinated groups were no different than the controls.

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