highly significantp <0,001
marginally significantp <0,05
Depending on the sample number ( n ), statistical test were done using either the Student’s t test with bilateral distribution and equal variance (results were considered significant for p <0.05 and labeled with *), or the Mann-Whitney rank sum test (results were considered statistically highly significant when p <0,001 (***); significant when p <0,01 (**); marginally significant when p <0,05.