Is metabotropic glutamate receptor 5 upregulated in prefrontal cortex in fragile X syndrome?

Results The mGluR5 density increased with marginal significance (+16%; P = 0.058) in the prefrontal cortex of FXS patients or carriers compared with matched healthy controls.

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A P value of less than 0.05 was considered statistically significant, between 0.05 to 0.1 as marginally significant and more than 0.1 as nonsignificant.

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Highly significant differences in mGluR5 density could not be measured, mainly because of the limited availability of postmortem human brain tissues from FXS patients; nevertheless, the results raise the important question of whether mGluR5 density is indeed increased in the brains of individuals with FXS.

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