Based on the highly significant accumulation of 4 in the roqM deletion strain and the absence of all downstream metabolites 5 till 7 , we concluded that roqM , encoding a MAK 1-monooxygenase like protein, is involved in the conversion of 4 to 5 .
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A branched biosynthetic pathway is involved in production of roquefortine and related compounds in Penicillium chrysogenum.
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