Diagnostic criteria, specific mutations, and genetic predisposition in gastrointestinal stromal tumors.

6 , 63 , 65 , 83 Recently, we reported that GISTs with a deletion of the two tyrosine residues of exon 11 (delTyr) arise in the small intestine, colon, or rectum in about 70% of cases, whereas those with delWK557–558 occur in the stomach in about 75% of cases, and that this difference was highly significant. 84 These data suggest possible different types of oncogenic events driving kit mutations in the different parts of the digestive tract.

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