Hypoxia-induced cytotoxic drug resistance in osteosarcoma is independent of HIF-1Alpha.

In 791T cells highly significant (p<0.001, 2-way ANOVA) resistance to cisplatin in hypoxia remains after transient transfection of HIF-1α short interfering RNA (siRNA) ( Figure 4E ), despite reduction in protein levels of HIF-1α and CA IX ( Figure 4F ).

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