highly significantP ≤1.99×10 −10
In the case of the consistently down-regulated TFs we found one highly significant model ( P ≤1.99×10 −10 ) composed of six elements corresponding to TFBS for E2FF, RXRF (Retinoid × receptor heterodimer-binding sites), KLFS (Kruppel-like factors) and ZF02 (C2H2 zinc finger transcription factors 2).