Barely Significant
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Nationwide survey of the development of drug-resistant pathogens in the pediatric field in 2007 and 2010: drug sensitivity of Streptococcus pneumoniae in Japan (second report).

J Infect Chemother · 2013 · PMC3682105 · PMID 23564331

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an increasing trendno p-value reported
The resistance rates were 56.2 % in period 3 and 76.9 % in period 4, more than half in both periods and showing an increasing trend.

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