Structural and functional studies of FKHR-PAX3, a reciprocal fusion gene of the t(2;13) chromosomal translocation in alveolar rhabdomyosarcoma.

PLoS One · 2013 · PMC3683129 · PMID 23799156

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highly significantno p-value reported

The fact that both FKHR-PAX3 and PAX3-FKHR fusion proteins can block myogenic differentiation and promote cell growth is highly significant because they foster a rich environment for the acquisition of additional mutations that contribute to tumorogenesis.

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