CD10 and CA19.9 immunohistochemical expression in transitional cell carcinoma of the urinary bladder.

The present study revealed a significant correlation between the WHO 2004 grade of urothelial carcinoma cases and the immunohistochemical expression of CA19.9 ( P value was 0.021), CA19.9 was over expressed immunohistochemically in low-grade urothelial carcinoma than in high-grade tumors, and these results were supported by studies done by Chuang and Liao[ 8 ] and Kajiwara et al .,[ 15 ] on the other hand no significant correlation was found between immunohistochemical scoring of CA19.9 and the WHO 2004 grade of urothelial carcinoma cases; despite that there was a trend toward significance ( P value 0.06) in which moderate and strong immunohistochemical scoring of CA19.9 was found more in low-grade tumors while negative staining was associated with high-grade tumors, taking in consideration that to the best of this knowledge; this study is the only study in which the 2004 grading system of urothelial carcinoma had been used in evaluating CA19.9 immunohistochemical expression.

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