The effect of pretreatment with clonidine on propofol consumption in opium abuser and non-abuser patients undergoing elective leg surgery.

But these days, we see an increasing trend of using it not just as an antihypertensive agent, but also as an anesthetic adjuvant.[ 1 2 ] Since clonidine is mainly an alpha-2 adrenergic agonist, it was used originally as an antihypertensive drug; but later on, it stared to be used as an adjuvant anesthetic, which is nowadays administered orally or through intravenous line or as an intrathecal agent.

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