close to significancep -value = 0.06
For long lag pairs, the independence hypothesis test was close to significance at the subtype level (11*12 CT, n individuals = 44, n transitions = 58, median MC Fisher's p -value = 0.06; Table S7 and S8 ), non-significant at the clade level (5*4 CT, sample size as above, median Fisher's p -value = 0.28; Table S9 ) and close to significance at the group level (2*2 CT, sample size as above, median Fisher's p -value = 0.07; Table S9 ).