The antioxidant N-acetylcysteine prevents HIF-1 stabilization under hypoxia in vitro but does not affect tumorigenesis in multiple breast cancer models in vivo.

PLoS One · 2013 · PMC3688768 · PMID 23840457

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a slight trendno p-value reported

Overall, the data indicate a slight trend towards increased proliferation in tumors from NAC-treated mice.

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