High correlation between in vivo [123I]β-CIT SPECT/CT imaging and post-mortem immunohistochemical findings in the evaluation of lesions induced by 6-OHDA in rats.

When estimating the density of TH- and DAT-reactive fibers in the rat striatum, the two different doses of 6-OHDA resulted in highly significant unilateral decrease in the striatal fiber density at both 2 and 4 weeks post-lesion as compared to the intact rat striatum (one-way ANOVA ( P < 0.001, F 4,22 = 32.564 (TH) and F 4,22 = 52.435 (DAT)) and Tukey post hoc test, n = 4 to 5 per group) (Figure 2 B,C; representative pictures in Figure 1 C,D).

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