Effects of Chronic D-Serine Elevation on Animal Models of Depression and Anxiety-Related Behavior.

In the novelty-suppressed feeding (NSF) test, Srr12 animals showed a highly significant reduction in the latency to approach the food compared to Wt mice ( Fig. 3C , one-way ANOVA F(1,28) = 16.89, p<0.01), whereas the general food intake in both transgenic mouse strains was not changed (data not shown) Again, we did not observe any sex (two-way ANOVA F(1,50) = 3.86, p = 0.055) or sex genotype interaction (two-way ANOVA F(1,50) = 2.78, p = 0.10).

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