Owing to the highly significant association between the four rare DPYD sequence variants (c.1905+1G>A, c.2846A>T, c.1601G>A or c.1679T>G) and grade 3 and 4 toxicity, the 24 patients with variant DPYD genotypes were excluded from subsequent analysis.
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Pharmacogenetic variants in the DPYD, TYMS, CDA and MTHFR genes are clinically significant predictors of fluoropyrimidine toxicity.
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