RanBP9 aggravates synaptic damage in the mouse brain and is inversely correlated to spinophilin levels in Alzheimer's brain synaptosomes.

At 12 months, APΔE9 mice reached the goal arm only 50% of the trials compared with 70% for the WT controls, reaching statistical significance ( P <0.01), while the APΔE9/RanBP9 triple-transgenic mice made correct choices only 34% of the times, which was also highly significant ( P <0.001).

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Results revealed a decreasing trend for spinophilin from Braak stage 2 to Braak stages 3, 5 and 6, though statistical significance was reached only for Braak stage 6 that showed 48% reduction ( P <0.05) ( Figure 8a and b ).

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