Glucose regulation of load-induced mTOR signaling and ER stress in mammalian heart.

Indeed, although not quite statistically significant, hearts perfused with this “physiological” mix of substrate at high workload showed a 2.5‐fold increase on average in G6P levels ( Figure 5 A) and increased phosphorylation of both downstream targets of mTOR, p70S6K and 4EBP1 ( Figure 5 B) compared with hearts perfused with NCS, which is similar to hearts perfused with glucose alone.

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