Are C-reactive protein associated genetic variants associated with serum levels and retinal markers of microvascular pathology in Asian populations from Singapore?

However, although highly significant, this SNP only explained approximately 0.45% of the CRP phenotypic variance among the Singaporean datasets.

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In all the 3 Singaporean Asian datasets, serum CRP was associated with the CRVE phenotype (p-value ≤6.56×10 −4 , Figure 1 ) and the CRP increasing allele (G allele) of rs2794520 was marginally significant for increased CRVE (p-value between 0.048 and 0.022) but, this association was not replicated in the larger CHARGE consortium European samples and overall meta-analysis revealed no statistical significance ( Table 4 ).

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