Barely Significant
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Ambushing the Ambush Hypothesis: predicting and evaluating off-frame codon frequencies in prokaryotic genomes.

BMC Genomics · 2013 · PMC3700767 · PMID 23799949

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highly significantno p-value reported
Although our results show the same highly significant statistical excess of OSCs in the organisms studied, they also show that several sense codons are present out-of-frame with similar or even greater excesses than the stop codons are.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.