Sphingosine kinase activity is not required for tumor cell viability.

PLoS One · 2013 · PMC3702540 · PMID 23861887

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highly significantno p-value reported

The 20 siRNAs targeting SPHK1 (panel A) or SPHK2 (panel B) are indistinguishable from the reference siRNAs, while toxic genes like PLK1 or POLR2A have highly significant effects on cell viability.

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