Prospective cohort study of the circadian rhythm pattern in allogeneic sibling donors undergoing standard granulocyte colony-stimulating factor mobilization.

In this prospective cohort study of 11 G-CSF mobilized allogeneic sibling donors, there was a highly significant rise in PB [CD34 + ] and [CD34 + CD38 – ] throughout day 4 ( P <0.0001), but no reductions in the morning of day 5, as might be expected with a circadian rhythm pattern.

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On day 5 of daily morning G-CSF administration, there was also a nonsignificant trend in 10 healthy volunteers towards a peak CD34 + count 2 hours after the G-CSF dose [ 19 ].

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