The WASH complex, an endosomal Arp2/3 activator, interacts with the Hermansky-Pudlak syndrome complex BLOC-1 and its cargo phosphatidylinositol-4-kinase type IIα.

In addition, functional annotation analysis indicated a highly significant enrichment of proteins annotated as “vesicle-mediated transport proteins” (13/124), as predicted, given the role of PI4KIIα in regulating AP-3–dependent vesicle biogenesis ( Figure 1E ; p = 1.19 × 10 −3 ; Supplemental Table S2).

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