Results from the 5-year, phase IV RENEW (Registry to Evaluate Novantrone Effects in Worsening Multiple Sclerosis) study.

BMC Neurol · 2013 · PMC3710498 · PMID 23841877

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a trend toward significanceno p-value reported

Lastly, use of Mitoxantrone and previous or concomitant use of oral Methotrexate was significantly associated with cardiotoxicity risk and there was a trend toward significance when oral Methotrexate was used after study entry (Figure 4 ).

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