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A randomised phase I study of etrolizumab (rhuMAb β7) in moderate to severe ulcerative colitis.

Gut · 2013 · PMC3711369 · PMID 22717454

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a slight trendno p-value reported
A slight trend of nonlinearity was observed at doses ≤1.0 mg/kg, possibly due to target-mediated clearance at lower etrolizumab serum concentrations.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.