The proto-oncoprotein FBI-1 interacts with MBD3 to recruit the Mi-2/NuRD-HDAC complex and BCoR and to silence p21WAF/CDKN1A by DNA methylation.

Nucleic Acids Res · 2013 · PMC3711425 · PMID 23658227

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may be significantno p-value reported

These data suggest that MBD3 can enhance the transcriptional repression of CDKN1A by FBI-1 and that the FBI-1-MBD interaction may be significant in cell cycle regulation by repressing p21 expression.

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