Insights into the clinical management of the syndrome of supine hypertension--orthostatic hypotension (SH-OH): the Irish Longitudinal Study on Ageing (TILDA).

Yet, the alpha(1)-adrenergic receptor pathway is known to be critical in the recovery from initial OH to prevent cerebral hypoperfusion and ultimately syncope [ 52 ], so the clinical relevance of alpha blockers in the SH-OH syndrome might be significant.

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