Although individual pigs showed high levels of T-cell response, the average proliferative responses of all vaccinated pigs did not show a highly significant increase in the stimulation indexes, compared with the animals inoculated with PBS, which was different from the T-cell response in guinea pigs.
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Foot-and-mouth disease virus-like particles produced by a SUMO fusion protein system in Escherichia coli induce potent protective immune responses in guinea pigs, swine and cattle.
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