DNA methyltransferase candidate polymorphisms, imprinting methylation, and birth outcome.

PLoS One · 2013 · PMC3724884 · PMID 23922667

Europe PMC DOI

hedged sentences

0.0020

closest p · 0.0× alpha

0.0520

boldest claim

The sentences

highly significantp = 0.002actually significant

The effect of DNMT3A genotype on birth weight and DNMT3B on length of gestation were the least significant before the exclusion and just below significance following the reduction in numbers; though the stronger DNMT3B effect on risk of prematurity remained highly significant (p = 0.002) after exclusion of the non-Caucasian pregnancies.

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borderline significantp = 0.052so close (0.05 < p ≤ 0.1)

There was a borderline significant association between birth weight, adjusted for gestational age and baby sex and methylation of LINE1 (−13.5 95% CI −27.2,0.1; p = 0.052; g/% change in methylation) and IGF2 (−6.1 95% CI −12.2, −0.1; p = 0.052; g/% change in methylation).

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borderline significanceno p-value reported

Simple Bonferonni correction results in borderline significance for the DNMT3L effects but we believe that this adjustment is too conservative.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.