highly significantP < 0.0001
The correlation of the DEC1-dependent signature was highly significant with the CD28-regulated gene list (P < 0.0001). 72% of the genes up-regulated by DEC1 were also up-regulated by CD28 co-stimulation, whereas 83% of the DEC1 down-regulated genes were again down-regulated by CD28 signaling ( Fig. 7, C and D , top).