tended toward significanceP = 0.073
MiR-141, miR-375 and miR-210 were significant at a P -value threshold of <0.01 in the second cohort ( P = 0.001, P = 0.021, P = 0.022, respectively) and miR-200a and miR-200c tended toward significance ( P = 0.073, P = 0.055, respectively) ( Fig. 1 C , upper ).