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Patent foramen ovale in patients with sickle cell disease and stroke: case presentations and review of the literature.

Case Rep Hematol · 2013 · PMC3730376 · PMID 23956892

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a nonsignificant trendno p-value reported
However, two population-based studies of first stroke in young individuals with PFO have found a nonsignificant trend towards a low but increased risk of stroke.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.