Under the same experimental conditions, there was no significant increase in DP5 expression and a nonsignificant trend for higher PUMA expression (data not shown); PUMA KD, however, failed to protect against CPA+IL-1 β -induced cell death (data not shown).
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Endoplasmic reticulum stress sensitizes pancreatic beta cells to interleukin-1β-induced apoptosis via Bim/A1 imbalance.
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