A rule-based kinetic model of RNA polymerase II C-terminal domain phosphorylation.

An increase in the absolute level of phosphorylation is expected where RNAPII pauses; however, additional changes in phosphorylation observed at the 5′ end of exon 2 (see point 5′-E2 in figure 4 a ) that occur concurrently with a decrease in RNAPII are highly significant as they may indicate signalling that occurs subsequent to the pause, rather than changes that can be ascribed to RNAPII density [ 12 ]. 5.

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