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The PI3K/Akt/mTOR pathway is implicated in the premature senescence of primary human endothelial cells exposed to chronic radiation.

PLoS One · 2013 · PMC3731291 · PMID 23936371

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an increasing trendno p-value reported
Employees in the nuclear industry at British Nuclear Fuels and Canadian nuclear workers showed an increasing trend for circulatory disease mortality associated with the radiation dose [5] , [6] .

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.