Clonal expansion analysis of transposon insertions by high-throughput sequencing identifies candidate cancer genes in a PiggyBac mutagenesis screen.

For instance, nine of our candidate cancer genes were also contained in the Cancer Gene Census list, which comprises 487 genes causally linked to cancer [ 11 ], representing a highly significant enrichment ( Abl2 , Braf , Fbxw7 , Foxp1 , Ipo11 , Mllt3 , Fas , Pten , and Nf1 ; p<0.0002, Fisher’s exact test).

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