marginally significantP =0.05
In univariate analysis, male sex, poorly differentiated histology, macroscopic vascular invasion, tumour size, anatomic resection, serum ALT>30 units l −1 , serum AFP>20 ng ml −1 and HAI were associated with poor recurrence-free survival, and Ishak stage 6 compared with Ishak stage 1–5 had a marginally significant impact on recurrence-free survival ( Table 2 , Figure 2C , P =0.05).