In another study of type 1 diabetic patients, regression of microalbuminuria was associated with a highly significant reduction in urine NAG excretion. 37 ROC analysis showed that urinary NAG was as sensitive as serum Cystatin for the prediction of microalbuminuria (83.3%), but had much higher specificity (77.8% versus 61.1%, respectively).
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Serum cystatin C and tubular urinary enzymes as biomarkers of renal dysfunction in type 2 diabetes mellitus.
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